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 The YSL Lab

 

Enzymes play a very wide range of physiological functions in human body, including signal transduction and metabolic pathways. Studying of the molecular and cellular functions of enzymes is crucially important for development of new therapeutic treatments and exploring unknown mechanisms of diseases.
Our research is mainly focusing on discovering of small-molecule based enzyme inhibitors/activators, the new substrate discovery for enzymes, biochemical and cellular functions of enzymes. We use biochemistry, molecular biology, cell biology, high-throughput screening, bioinformatics, computer-aided drug design, enzyme kinetics, cell models of disease, chemical biology, molecular pharmacology and other methods to study the key scientific and clinical issues in a translational medicine manner.
On this regards, we have discovered a variety of new inhibitors for important enzymes as well as some functional new substrates. The related underlying molecular and cellular mechanisms of cancer and Alzheimer’s disease were also elaborately studied in the lab. Our results have been were published in the chemical biology and pharmacology fields of famous journals, e.g. Chem. Commun., FASEB J., ACS Chem. Biol. (Cover Story) and Mol. Cancer Ther.

The international YSL research team is composed of young scientists from different research backgrounds including biochemistry, molecular biology, drug design, screening assay development and genomics. We are seeking for outstanding personnel to join our team as well as scientific collaborations and clinical patients to join us to fight diseases in China and the rest of the world.

 

 

 

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