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1. Feng Liu#, Kai Xu#, Zhijue Xu, Matilde de las Rivas, Congrong Wang, Xing Li, Jishun Lu, Yueyang Zhou, Ignacio Delso, Pedro Merino, Ramon Hurtado-Guerrero*, Yan Zhang* and Fang Wu*. The small molecule luteolin inhibits N-acetyl-α-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein[J]. Journal of Biological Chemistry, 2017, 292:jbc.M117.814202.

2. Hermeto Gerber#, Fang Wu#, Mitko Dimitrov , Guillermo M. Garcia Osuna , and Patrick C. Fraering. Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production. Journal of Biological Chemistry, 2017: jbc. M116. 754101.

3. Yinzhong Lu, Jun Wan#, Zhifeng Yang#, Xiling Lei, Qi Niu, Lanxin Jiang, Willemijn M. Passtoors, Aiping Zang, Patrick C. Fraering, and Fang Wu*. Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells. The FASEB Journal, 2016: fj. 201600702R.

4. ShuyangXu#, XianminZhu#, Hong Li#, Youtian Hu, JinpingZhou, Di He, Yun Feng, Lina Lu, Guizhen Du, Youjin Hu, Tiancheng Liu, ZhenWang, Guohui Ding, JiayuChen, ShaorongGao, Fang Wu, ZhigangXue, Yixue Li & Guoping Fan. The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat. Scientific Reports, 2016 Jul 5;6:28508.

5. Shengtao Xu, Shanshan Lu, Hong Yao, Hao Cai, Xiaoming Miao, Fang Wu*, Dong-Hua Yang, Xiaoming Wu, Weijia Xie, Hequan Yao, Zhe-sheng Chen, Jinyi Xu. Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria. J Med. Chem. 2016 in press

6. Xiling Lei#, Jing Yu#, Qi NIu, Jianhua Liu, Patrick C. Fraering and Fang Wu*. The FDA-approved natural product dihydroergocristine reduces the production of Alzheimer's disease amylod-abeta peptides. Scientific Reports 2015 5:16541 

7. Jie Ren, Yuanyuan Zhang, Huizi Jin, Jing Yu, Yueyang Zhou, Fang Wu* and Weidong Zhang.Novel Inhibitors of Human DOPA Decarboxylase Extracted from Euonymus glabra Roxb.ACS Chem Biol. 2014 9(4) 897-903. Cover Story ( IF: 5.4,上海交大SCI B类期刊)

Cited by Sina.com, 文汇报, 中国日报, 京华时报, 中国科学报, Sciencenet.com, 163.com, chinanews.com, bioon.com, ebiotrade.com等

8. Hilal A. Lashuel, Simona Eleuteri, Saviana Di Giovanni, Edward Rockenstein, Mike Mante, Antony Adame, Margarita Trejo, Fang Wu, Patrick C. Fraering, Eliezer Masliah. Novel Mechanism-based Inhibitors of Ab Aggregation and Toxicity. Neurobiology of Aging 2014:35(3) 720–721

9. Yueyang Zhou#, Jing Yu#, Xiling Lei, Jianying Wu, Qi Niu, Yixuan Zhang, Hong Liu, Philipp Christen, Heinz Gehring and Fang Wu*. High-throughput tandem-microwell assay identifies inhibitors of hydrogen sulfide signaling pathway. Chem Commun. 2013, 49, 11782-84. (IF: 6.7,上海交大SCI A类期刊)

10. Fang Wu, Philipp Christen, Heinz Gehring. A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase. FASEB J.  25 (2011), 2109-2122

11. Fang Wu, Claude Schweizer, Nikita Rudinskiy, David M. Taylor, Aleksey Kazantsev, Ruth Luthi-Carter and Patrick C. Fraering. Novel g-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2 and PS1. FASEB J.  24 (2010), 2464-74

12. Fang Wu and Heinz Gehring.Structural requirements for novel coenzyme-substrate derivatives to inhibit intracellular human ornithine decarboxylase and cell proliferation. FASEB J. 23 (2009), 565-74

13. Ingrid B.Müller#, Fang Wu#, Bärbel Bergmann, Julia Knöckel, Rolf D. Walter, Heinz Gehring, Carsten Wrenger. Poisoning pyridoxal 5- phosphate (PLP)-dependent enzymes: A new strategy to target the malaria parasite Plasmodium falciparum. PloS ONE 4 (2009), e4406. Highlighted by peers in Faculty1000 Biology Pharmacology & Drug Discovery section.  Hanjo Hellmann: Faculty of 1000 Biology, 16 Feb 2009 http://www.f1000biology.com/ article/id/ 1148087 /evaluation

14. Fang Wu, Jing Yu and Heinz Gehring. Inhibitory and structural studies of novel coenzyme-substrate analogs of human histidine decarboxylase. FASEB J. 22 (2008), 890-7

15. Fang Wu, Doris Grossenbacher and Heinz Gehring. Transition state based-inhibitor of human ornithine decarboxylase inhibiting growth of tumor cells. Molecular Cancer Therapeutics, 6 (2007), 1831-9

 

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