1．Alcohol

The research data suggests that moderate alcohol consumption is amodifiable protective factor, while heavy alcohol consumption may promotedementia. Thus, starting or increasing alcohol consumption in late life for prevention of Alzheimer’s disease is not recommended.

2．Blood pressure

The data on the relationship between blood pressure and AD and total dementia suggest that there is an age-dependent relationship. However,Few studies have specifically considered the association between midlife blood pressure and AD.

3．Diabetes mellitus

The evidence is consistent with an association between diabetes diagnosis and increased risk of AD, suggesting that measures to prevent diabetes -- such as exercise, weight reduction and diet control.

4．Head injury

While head injury likely increases the risk of developing dementia, epidemiologic evidence linking head injury to AD dementia is less clear.

5．Homocysteine

The evidence from observational epidemiologic studies suggests that higher levels of plasma total homocysteine(tHcy) may be  associated with an increased risk of incident Alzheimer's disease.

6．Hormone therapy

Randomized controlled trial results in postmenopausal women suggest that hormone therapy increases dementia risk, and also has adverse effects on other health outcomes.