学习经历
2003.9~2007.6，天津师范大学化学与生命科学学院生物科学专业学士
2007.9~2012.12， 武汉大学生命科学学院微生物学专业博士
工作经历
2013.8~2014.8 美国约翰斯霍普金斯大学医学院博士后
研究兴趣
酶小分子抑制剂的筛选和设计及作用机制
靶向离子通道药物的研究与开发
主要论文
l First or co-first author articles:
(1) Youtian Hu,# Lu Wang,# Xu Han,# Yueyang Zhou, Tonghui Zhang, Li Wang, Ting Hong, Wei Zhang, Xun-Xiang Guo, Jielin Sun, Yingxin Qi, Jing Yu,* Hong Liu,* Fang Wu.* Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase. Journal of Medicinal Chemistry. 2019, 62 (3), 1677-1683.
(2) Rui Zhan,# Youtian Hu,# Lidong Shao,# Xu-Jie Qin, Fang Kuang, Shouzhen Du, Fang Wu,* and Yegao Chen.* Horisfieldones A and B, Two Aromatic Ring-Contracted Dimeric Diarylpropanes with Human DOPA Decarboxylase Inhibitory Activity from Horsfieldia kingie. Organic Letters. 2019, 21(10):3678-3681.
(3) Youtian Hu, Xiaoyun Yu, Shaoyong Yu.* QX-314 inhibits acid-induced activation of esophageal nociceptive C fiber neurons. Neurogastroenterol Motil, 2019, 31(4):e13543.
(4) Youtian Hu, Juan Feng, Fang Wu.* The Multiplicity of Polypeptide GalNAc-Transferase: Assays, Inhibitors and Structures. ChemBioChem 2018,19(24): 2503-2521.
(5) Zhenyu Liu,# Youtian Hu,# Xiaoyun Yu, Jiefeng Xi, Xiaoming Fan, Chung-Ming Tse, Allen C. Myers, Pankaj J. Pasricha, Xingde Li, and Shaoyong Yu.* Allergen challenge sensitizes TRPA1 in vagal sensory neurons and afferent C-fiber subtypes in guinea pig esophagus. American journal of physiology Gastrointestinal and liver physiology 2015, 308(6):G482-488.
(6) Xiaoyun Yu,# Youtian Hu,# Fei Ru, Marian Kollarik, Bradley J. Undem, and Shaoyong Yu.* TRPM8 function and expression in vagal sensory neurons and afferent nerves innervating guinea pig esophagus. American journal of physiology Gastrointestinal and liver physiology 2015, 308(6):G489-496.
(7) Zongyun Chen,# Youtian Hu,# Jing Hong,# Jun Hu, Weishan Yang, Fang Xiang, Fan Yang, Zili Xie, Zhijian Cao, Wenxin Li, Donghai Lin,* and Yingliang Wu.* Toxin acidic residue evolutionary function-guided design of de novo peptide drugs for the immunotherapeutic target, the Kv1.3 channel. Scientific Reports 2015, 5:9881.
(8) Youtian Hu,# Jing Chen,# Bin Wang,# Weishan Yang, Chuangeng Zhang, Jun Hu, Zili Xie, Zhijian Cao, Wenxin Li, Yingliang Wu,* Zongyun Chen.* Engineering a peptide inhibitor towards the KCNQ1/KCNE1 potassium channel (IKs). Peptides 2015, 71:77-83.
(9) Zongyun Chen,# Youtian Hu,# Jun Hu,# Weishan Yang, Jean-Marc Sabatierd, Michel De Waarde, Zhijian Cao, Wenxin Li, Song Han,* Yingliang Wu.* Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues. Biochemical and Biophysical Research Communications 2014, 447(1):70-76.
(10) Youtian Hu,# Zhenyu Liu,# Xiaoyun Yu, Pankaj J. Pasricha, Bradley J. Undem, and Shaoyong Yu.* Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis. American journal of physiology Gastrointestinal and liver physiology 2014, 307(2):G149-157.
(11) Youtian Hu,# Jun Hu, Tian Li, Jingjing Wei, Jing Feng, Yimei Du, Zhijian Cao, Wenxin Li, and Yingliang Wu.* Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2. Cell & bioscience 2014, 4, 18.
(12) Jing Feng,# Youtian Hu,# Hong Yi,# Shijin Yin, Song Han, Jun Hu, Zongyun Chen, Weishan Yang, Zhijian Cao, Michel De Waard, Jean-Marc Sabatier, Wenxin Li and Yingliang Wu.* Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins. The Journal of Biological Chemistry 2013, 288(18):12544-12553.
(13) Zongyun Chen,# Youtian Hu,# Weishan Yang, Yawen He, Jing Feng, Bin Wang, Ruiming Zhao, Jiuping Ding, Zhijian Cao, Wenxin Li,* Yingliang Wu.* Hg1, novel peptide inhibitor specific for Kv1.3 channels from first scorpion Kunitz-type potassium channel toxin family. The Journal of Biological Chemistry 2012, 287(17):13813-13821.
(14) Zongyun Chen,# Danyun Zeng,# Youtian Hu,# Yawen He, Na Pan, Jiuping Ding, Zhijian Cao, Maili Liu, Wenxin Li, Hong Yi,* Ling Jiang,* and Yingliang Wu, * Structural and functional diversity of acidic scorpion potassium channel toxins. PloS one, 2012, 7(4):e35154.
l Co-author articles:
(1)Jun-Sheng Zhang, Youtian Hu, Kun-Sheng Song, Fang Wu, Kongkai Zhu, De-Feng Xu, Hua Zhang (2021). Diterpenoid glucosides with cystathionine gamma-lyase inhibitory activity from Tinospora sinensis. Bioorg Chem, 116, 105400.
(2)Tonghui Zhang, Youtian Hu, Fang Wu. Recombinant Expression and Purification of Cbl-b Protein and Establishment of Activity Detection Method. Genomics and Applied Biology 2019,38(7):2981-2989.
(3) Wang Li,# Hao Cai,# Youtian Hu, Fan Liu, Shengshuo Huang, Yueyang Zhou, Jing Yu,* Jinyi Xu, * and Fang Wu.* A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis. Cell Death & Disease 2018, 9(10):1005.
(4) Shuyang Xu,# Xianmin Zhu,# Hong Li,# Youtian Hu, Jinping Zhou, Di He, Yun Feng, Lina Lu, Guizhen Du, Youjin Hu, Tiancheng Liu, Zhen Wang, Guohui Ding, Jiayu Chen, Shaorong Gao, Fang Wu, Zhigang Xue, Yixue Li, and Guoping Fan.* The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat. Scientific reports, 2016, 6:28508.
(5) Xiaoyun Yu,# Youtian Hu, and Shaoyong Yu.* Effects of acid on vagal nociceptive afferent subtypes in guinea pig esophagus. American journal of physiology Gastrointestinal and liver physiology, 2014, 307(4):G471-478.
(6) Jian Ma,# Youtian Hu, Mingxiong Guo, Zan Huang, Wenxin Li,* Yingliang Wu.* hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562. PloS one, 2013, 8(12):e84903.
(7) Zhijian Cao, # Yao Yu, Yingliang Wu, Pei Hao, Zhiyong Di, Yawen He, Zongyun Chen, Weishan Yang, Zhiyong Shen, Xiaohua He, Jia Sheng, Xiaobo Xu, Bohu Pan, Jing Feng, Xiaojuan Yang, Wei Hong, Wenjuan Zhao, Zhongjie Li, Kai Huang, Tian Li, Yimeng Kong, Hui Liu, Dahe Jiang, Binyan Zhang, Jun Hu, Youtian Hu, Bin Wang, Jianliang Dai, Bifeng Yuan, Yuqi Feng, Wei Huang, Xiaojing Xing, Guoping Zhao, Xuan Li,* Yixue Li,* and Wenxin Li.* The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nature communications, 2013, 4:2602.